Publications

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Amy G Prater, Heer H Mehta, Kathryn Beabout, Adeline Supandy, William R Miller, Truc T Tran, Cesar A Arias, Yousif Shamoo2021 Daptomycin resistance in Enterococcus faecium can be delayed by disruption of the LiaFSR stress response pathway. DOI: 10.1128/AAC.01317-20

Mehta HH, Shamoo Y. 2020 Pathogenic Nocardia: A diverse genus of emerging pathogens or just poorly recognized? PLoS Pathog. doi: 10.1371/journal.ppat.1008280.

Khan A, Davlieva M, Panesso D, Rincon S, Miller WR, Diaz L, Reyes J, Cruz MR, Pemberton O, Nguyen AH, Siegel SD, Planet PJ, Narechania A, Latorre M, Rios R, Singh KV, Ton-That H, Garsin DA, Tran TT, Shamoo Y, Arias CA. 2019Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1916037116.

Prater AG, Mehta HH, Kosgei AJ, Miller WR, Tran TT, Arias CA, Shamoo Y. 2019. Environment Shapes the Accessible Daptomycin Resistance Mechanisms in Enterococcus faecium. Antimicrob Agents Chemother. doi: 10.1128/AAC.00790-19.

Mehta H.H., Prater A.G., Beabout K., Elworth R.A.L., Karavis M., Gibbons H.S. and Shamoo Y. 2019. The Essential Role of Hypermutation in Rapid Adaptation to Antibiotic Stress. Antimicrob Agents Chemother. 63(7).

Rincon S., Panesso D., Miller W.R., Singh K.V., Cruz M.R., Khan A., Dinh A.Q., Diaz L., Rios R., Shamoo Y., Reyes J., Tran T.T., Garsin D.A. and Arias C.A. 2019. Disrupting Membrane Adaptation Restores In Vivo Efficacy of Antibiotics Against Multidrug-Resistant Enterococci and Potentiates Killing by Human Neutrophils. J Infect Dis.

Miller W.R., Tran T.T., Diaz L., Rios R., Khan A., Reyes J., Prater A.G., Panesso D., Shamoo Y. and Arias C.A. 2019. LiaR-independent pathways to daptomycin resistance in Enterococcus faecalis reveal a multilayer defense against cell envelope antibiotics. Mol Microbiol. 111(3): 811-24.

Mehta H, Weng J, Prater A, Elworth RAL, Han X, Shamoo Y. 2018. Pathogenic Nocardia cyriacigeorgica and Nocardia nova Evolve To Resist Trimethoprim-Sulfamethoxazole by both Expected and Unexpected Pathways. Antimicrob Agents Chemother. doi: 10.1128/AAC.00364-18.

Mehta H.H., Prater A.G. and Shamoo Y. 2018. Using experimental evolution to identify druggable targets that could inhibit the evolution of antimicrobial resistance. J Antibiot (Tokyo). 71(2): 279-86.

Davlieva M., Wu C., Zhou Y., Arias C.A. and Shamoo Y. 2018. Two Mutations Commonly Associated with Daptomycin Resistance in Enterococcus faecium LiaS(T120A) and LiaR(W73C) Appear To Function Epistatically in LiaFSR Signaling. Biochemistry. 57(49): 6797-805.

Perez AM, Gomez MM, Kalvapalle P, O'Brien-Gilbert E, Bennett MR, Shamoo Y. 2017. Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. Mol Syst Biol. doi: 10.15252/msb.20177635.

Wang X., Davlieva M., Reyes J., Panesso D., Arias C.A. and Shamoo Y. 2017. A Novel Phosphodiesterase of the GdpP Family Modulates Cyclic di-AMP Levels in Response to Cell Membrane Stress in Daptomycin-Resistant Enterococci. Antimicrob Agents Chemother. 61(3).

Montealegre M.C., Roh J.H., Rae M., Davlieva M.G., Singh K.V., Shamoo Y. and Murray B.E. 2017. Differential Penicillin-Binding Protein 5 (PBP5) Levels in the Enterococcus faecium Clades with Different Levels of Ampicillin Resistance. Antimicrob Agents Chemother. 61(1).

Beabout K., McCurry M.D., Mehta H., Shah A.A., Pulukuri K.K., Rigol S., Wang Y., Nicolaou K.C. and Shamoo Y. 2017. Experimental Evolution of Diverse Strains as a Method for the Determination of Biochemical Mechanisms of Action for Novel Pyrrolizidinone Antibiotics. ACS Infect Dis. 3(11): 854-65.

Davlieva M., Tovar-Yanez A., DeBruler K., Leonard P.G., Zianni M.R., Arias C.A. and Shamoo Y. 2016. An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State. J Mol Biol. 428(22): 4503-19.

Beabout K., Hammerstrom T.G., Perez A.M., Magalhaes B.F., Prater A.G., Clements T.P., Arias C.A., Saxer G. and Shamoo Y. 2015. The ribosomal S10 protein is a general target for decreased tigecycline susceptibility. Antimicrob Agents Chemother. 59(9): 5561-6.